Cervical cancer
Conditions
Interventions
Primary cervical cancer:None
Recurrent cervical cancer:None
Sponsors
The Second Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
Female
Age
25 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Primary cervical cancer: (1) The primary lesion is in the cervix, not from metastasis of other lesions; (2) This is the first visit diagnosis, and the patient has not undergone surgery or preoperative neoadjuvant chemoradiotherapy; (3) The enrolled patients did not use antibiotics within 2 weeks and had no sexual activity or vaginal irrigation within 72 hours; (4) Cervical cancer has been diagnosed by pathological biopsy (5) Aged between 25 and 75 years; 2. Recurrent cervical cancer: (1) After primary cervical cancer undergoes radical surgery, radiotherapy, and chemotherapy, achieves a period of remission and then reaches the stage of clinical cure, a new tumor lesion of the same type as the primary tumor is found again; (2) In the case of vaginal metastasis, the pathological type of biopsy was the same as that of primary cervical cancer; in the case of pelvic or distant metastasis, imaging examination suggested metastasis; (3) Patients who did not receive radiotherapy, chemotherapy, or surgery after metastasis; (4) The enrolled patients did not use antibiotics within 2 weeks and had no sexual activity or vaginal irrigation within 72 hours (5) Aged between 25 and 75 years; 3. In accordance with the above diagnosis, the specimens can only be collected after the informed consent and signature of the subjects.
Exclusion criteria
Exclusion criteria: 1.Patients with primary cervical cancer who have received neoadjuvant chemoradiotherapy, targeted therapy, or cervical conization before surgery; or patients with recurrent cervical cancer who have received chemoradiotherapy or surgery; 2.Patients complicated with endometrial cancer, ovarian cancer, breast cancer, and other reproductive tract tumors; 3.Patients who are pregnant, in menstruation, or in lactation; 4.Patients who have taken immunosuppressants or glucocorticoids for a long time; 5.Patients complicated with severe diseases of the heart, liver, kidneys, hematopoietic system, or mental diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vaginal microbial flora; | — |
Secondary
| Measure | Time frame |
|---|---|
| Age;Number of pregnancies ;height ;Tumor size;blood routine examination;Age of first sexual experience;Serum squamous cell-associated antigen (SCCA);Number of miscarriages;weight;pathological pattern;pathological grading;clinical stages;Presence or absence of lymph node metastasis;Human papillomavirus infection;Thin-layer liquid-based cytology; | — |
Countries
China
Contacts
Public ContactTan Buzhen
The Second Affiliated Hospital of Nanchang University
Outcome results
None listed