type 2 diabetes complicated with nonalcoholic fatty liver disease
Conditions
Sponsors
Yuebei People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age: 18-75 years old, gender and nationality are not limited 2. Patients are diagnosed with type 2 diabetes according to WHO diabetes diagnostic criteria, and clinically diagnosed with nonalcoholic fatty liver disease (NAFLD diagnosis is made according to the guidelines of 2018 edition of the American Society for the study of liver diseases and NAFLD Asia Pacific Working Group); 3. Body mass index >= 22 kg / m2 and < 35 kg / m2, and previous body weight is stable (body weight change of at least 3 months <= 10%); 4. Glutamic pyruvic transaminase and glutamic oxalic transaminase <= 120 U / L; 5. All female subjects were postmenopausal or had undergone contraceptive operations, or took contraceptive measures 3 months before screening and throughout the study; 6. Understand the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Mentally disordered or unable to sign informed consent; 2. Patients with any history of liver disease other than NAFLD (including metabolic, autoimmune liver disease or viral hepatitis, alcoholic liver disease, hepatolenticular degeneration and other specific liver diseases that can lead to fatty liver) or cirrhosis; 3. Received the following drugs in the past 3 months: SGLT-2 inhibitor, thiazolidinediones, GLP-1 receptor agonist, DPP-4 inhibitor, polyene phosphatidylcholine, glycyrrhizic acid preparation, bicyclol, reduced glutathione, S-adenosylmethionine, silymarin, obecholate or ursodeoxycholic acid, betaine, fish oil, phosphodiesterase inhibitor, geferozil, tamoxifen, amiodarone, sodium valproate, methotrexate Glucocorticoids, probiotics and / or long-term antibiotic use (greater than 1 week); Or any other medication history related to fatty liver; 4. Acute complications of diabetes, such as ketoacidosis, hypertonic coma or hypoglycemia; 5. Acute infection or perioperative period; 6. Heart failure; 7. Renal insufficiency (estimated GFR = 1 month and / or whose drug compliance is less than 70%; 13. Daily alcohol intake: more than 30g for men and more than 20g for women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CT ratio of liver / spleen;liver function; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood glucose;intestinal microbiota; | — |
Countries
China
Contacts
Public ContactXiong Zhouyi
Yuebei People's Hospital
Outcome results
None listed