Effects of intraoperative inspired oxygen fraction on immediate graft flow in patients undergoing off-pump coronary artery bypass grafting: a single-blind, randomized controlled clinical trial

Effects of intraoperative inspired oxygen fraction on immediate graft flow in patients undergoing off-pump coronary artery bypass grafting: a single-blind, randomized controlled clinical trial - Influence of intraoperative FiO2 on immediate graft flow in patients undergoing OPCABG

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200064283

Enrollment

Unknown

Registered

2022-10-01

Start date

2022-10-01

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

off-pump coronary artery bypass grafting

Interventions

Low FiO2 group (group L):FiO2 remained unchanged after graft vessel anastomosis

High FiO2 group (group H):Adjust FiO2 to 100% after graft vessel anastomosis and maintain for 20 minutes

Eligibility

Sex/Gender

All

Age

50 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. 50 to 75 years old; 2. elective OPCABG surgery

Exclusion criteria

Exclusion criteria: 1. Moderate to severe lung disease; 2. Moderate to severe pulmonary hypertension; 3. Atrial fibrillation and other serious arrhythmias; 4. Heart failure or angina pectoris still occurs within 24 hours before surgery; 5. Preoperative LVEF30kg/m2; 8. Combined with other heart diseases requiring surgical treatment or previous open heart surgery; 9. The patient refuses to participate; 10. Other circumstances that the investigator or surgeon deems inappropriate to participate.

Design outcomes

Primary

Measure	Time frame
blood flow in grafted vessels;	—

Secondary

Measure	Time frame
pulsatility index of grafted vessels;radial artery invasive arterial pressure;heart rate(HR);central venous pressure(CVP);stroke volume(SV);stroke volume variability;cardiac output(CO);systemic vascular resistance(SVR);	—

Countries

China

Contacts

Public ContactHongli Chen

Qilu Hospital of Shandong University

chl0910@126.com+86 18560083799

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026