untreated gastric or gastroesophageal junction adenocarcinoma
Conditions
Interventions
Test group:PDT+ICI+chemotherapy
Control group:ICI+chemotherapy
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: All patients who meet the following criteria will be enrolled: 1. 18-65 years old; 2. untreated gastric or gastroesophageal junction adenocarcinoma confirmed by histopathological examination; 3. advanced or metastatic stage; 4. ECOG score 0-2; 5. expected survival >6 months; 6. having at least one measurable lesion; 7. adequate bone marrow, kidney and liver function defined as neutrophil count>= 1.5×10^9/L, platelet count >=100×10^9/L, creatinine<= 1.5 times the upper limit of normal (ULN), total bilirubin<= 1.5 times the ULN, and aspartate transaminase and alanine aminotransferase <= 5.0 times the ULN; 8. and providing a signed informed consent.
Exclusion criteria
Exclusion criteria: Any participants will be excluded when they have one of the following conditions: 1. multiple primary tumors; 2. prior usage of immunomodulator drugs or any medicines having an direct impacts on the immune system; 3. pregnancy or lactation for women; 4. history of allergy to the tested medications or light sensitiveness; 5. contraindication to gastroscopy; 6. comorbidities including autoimmune disease, severe cardiovascular disease, mental illness or severe neurosis, gastrointestinal bleeding and other sever diseases; 7. other inappropriate condition for inclusion determined by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR;PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactHao Chen
Lanzhou University Second Hospital
Outcome results
None listed