contrast nephropathy
Conditions
Interventions
Nicorandil routine dose group:On the basis of hydration, add oral nicorandil 5mg, TID from 1 day before operation to 4 days after operation
Nicorandil increased dose group:On the basis of hydration, add oral nicorandil 10mg, TID from 1 day before operation to 4 days after operation
Sponsors
Dongguan People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The study is planned to enroll patients with renal insufficiency (defined as EGFR <= 60ml / min / 1.73m2) who will undergo coronary intervention from October 1, 2022 to September 30, 2024, aged 18-80 years, with contrast agent dosage greater than 60ml, and voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with creatinine clearance rate <= 30ml / min / 1.73m2 and requiring hemodialysis; 2. Patients with contrast agent dosage < 60ml; 3. Patients allergic to nicorandil; 4. Known history of severe liver dysfunction; 5. Disease with systemic infection or its complications; 6. Previous malignant tumor history; 7. Glaucoma patients; 8. Pregnancy or lactation (pregnant women who may be pregnant should be examined for pregnancy); 9. Unable to comply with the trial protocol or follow-up requirements, or the researcher thinks that participating in the trial may cause the patient to face greater risks, or the researcher thinks that the enrollment of the subject may affect the special evaluation of the trial; 10. Other investigators considered that the patients were not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of contrast nephropathy; | — |
Countries
China
Contacts
Public ContactSuxia Guo
Dongguan People's Hospital
Outcome results
None listed