The effect of dexmedetomidine on atrial fibrillation after cardiac surgery in adults and the molecular mechanism of TLR4/MyD88/NF-?B signaling pathway

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200064263

Enrollment

Unknown

Registered

2022-10-01

Start date

2022-10-01

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation

Interventions

D1:Dexmedetomidine 1 µg/kg/h continuous infusion for 24 hours

D2:Dexmedetomidine 0.5µg/kg/h continuous infusion for 24 hours

Group C:Physiological saline was continuously pumped at the same rate for 24 hours

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients aged >= 18 years who underwent cardiac surgery were admitted to the ICU with mechanical ventilation after surgery.

Exclusion criteria

Exclusion criteria: 1. Second or third degree atrioventricular block 2. Dexmedetomidine or amiodarone used within 30 days 3. EF = 40kg/m2 10 patients with secondary surgery.

Design outcomes

Primary

Measure	Time frame
Atrial Fibrillation;	—

Countries

China

Contacts

Public ContactWenzhu Wang

Ji'ning First People's Hospital

wwz7444@126.com+86 15898788836

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026