Delayed neurocognitive recovery
Conditions
Interventions
Sevoflurane Group:Inhalation of sevoflurane
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age: >= 60 years and = 2 hours; 4. Voluntarily sign the informed consent; 5. The background group consisted of non-operative elderly with comparable age and education level to the patients.
Exclusion criteria
Exclusion criteria: 1. Central nervous system diseases and mental diseases; 2. Serious cardiovascular, respiratory, liver or kidney diseases; 3. Preoperative MMSE<23; 4. Taking of sedatives or antidepressants; 5. Patients dependent on alcohol or drugs (consume of more than 100ml of 40 proof alcohol per day in the past 3 months); 6. Patients with a history of surgery within the past one year; 7. Patients with communication disabilities (language impairment, severe visual or hearing impairment).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delayed neurocognitive recovery at 7 days after surgery in intravenous anesthesia group and inhalation anesthesia group; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma inflammatory factor(TNF-a, IL-1ß, IL-6, IL-17A, CRP);Nervous system related factors (Tau, NfL, GFAP, Aß, NSE); | — |
Countries
China
Contacts
Public ContactKe Jianjuan
Zhongnan Hospital of Wuhan University
Outcome results
None listed