heart failure
Conditions
Interventions
treatment group:intermittent repeated levosimendan infusions
Conrol group:Optimal drug treatment and capacity management education
Sponsors
Affiliated Dongguan Hospital, Southern Medical University (Dongguan People's Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Older than 18 years old; LVEF < 35%; NYHA cardiac function classification ?-? in recent 3 months; There was no low cardiac output at enrollment; No pulmonary or systemic circulation congestion requiring emergency medical treatment at enrollment; The patient has been treated with the best medication (except for intolerance or contraindications); The patient was informed and signed the informed consent
Exclusion criteria
Exclusion criteria: 1. Left ventricular outflow tract obstruction; 2. Primary valvular disease without surgical correction; 3. Severe ventricular arrhythmias; 4. Acute coronary syndrome within 3 months; 5. Stroke in 3 months; 6. hypertrophic cardiomyopathy or restrictive cardiomyopathy; 7. He had used milrinone, dopamine and dobutamine within 3 days. 8. within 28 days had used levosimendan; 9. Blood potassium < 3.5mmol/L; Creatinine clearance rate < 30ml/min/m2; 10. We plan to implant CRT, ICD, CCM, heart transplant, and left ventricular assist device within one year. 11. Patients are participating in additional clinical trials; 12. Clinical conditions that were considered inappropriate for enrollment by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality;Cardiovascular death;left ventricular strain and time to peak; | — |
Countries
China Mainland (PRC)
Contacts
Public ContactSuxia Guo
Affiliated Dongguan Hospital, Southern Medical University (Dongguan People's Hospital)
Outcome results
None listed