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Clinical study on titrating the best positive end-expiratory pressure by driving pressure to reduce postoperative pulmonary complications in elderly patients undergoing prone spine surgery

Clinical study on titrating the best positive end-expiratory pressure by driving pressure to reduce postoperative pulmonary complications in elderly patients undergoing prone spine surgery: a randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200064258
Enrollment
Unknown
Registered
2022-10-01
Start date
2022-10-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pulmonary complications

Interventions

Titration PEEP group:titrating PEEP by driving pressure
Fixed PEEP group:PEEP=5 cmH2O
Conventional ventilation group:VT = 8ml/kg PEEP=0 cmH2O

Sponsors

Affiliated Sport Hospital of Chengdu Sport University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged >= 65 years;ASA classification II-III; 2. Will undergo prone spine surgery;Operation time 2 -5 hours; 3. ARISCAT score = 26; 4. Could understand and sign the inform consent.

Exclusion criteria

Exclusion criteria: 1. Cannot cooperate for any reason or not suitable for investigator; 2. body-mass index of 30 or higher; 3. had done preoperative mechanical ventilation within the 2 weeks preceding surgery; 4. Acute lung injury or acute respiratory distress syndrome history within 3 months before operation; 5. severe liver and kidney dysfunction, lung dysfunction, and intracranial hypertension; 6.had a progressive neuromuscular illness 7. had a requirement for emergency surgery; 8. Other clinical trials participation.

Design outcomes

Primary

MeasureTime frame
postoperative pulmonary complications;—

Secondary

MeasureTime frame
the level of PEEP;Hemodynamic index;inflammatory factor;Blood gas analysis;Respiratory mechanical index;The severity of postoperative pulmonary complications was graded;Hospital stays;hospital costs;—

Countries

China

Contacts

Public ContactGong Yao

Affiliated Sport Hospital of Chengdu Sport University

994978996@qq.com+86 18981876434

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026