General anesthesia
Conditions
Interventions
Control group:Normal saline
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. ASA I-III objects; 2. Participants are older than 18 years. 3. 18 <= BMI <= 29.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to experimental drugs or have other contraindications; 2. With serious heart, lung, liver, kidney and brain diseases; 3. Severe blood system dysfunction; 4. Patients with history of mental disorders, chronic pain, or abnormal pain perception; 5. Recent history of pain, including surgery and trauma; 6. Long-term use of sedative analgesics or dependence on sedative analgesics patients, alcoholism patients; 7. Pregnant and lactating women; 8. For other reasons, they were not considered suitable subjects for study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cognitive impairment; | — |
Secondary
| Measure | Time frame |
|---|---|
| pain score;Postoperative analgesic drug use;Adverse events;Inflammatory factors;stress level;Dosage of propofol;Temperature change;Change in anxiety level;BIS level;Hemodynamic fluctuations;Use of vasoactive drugs;Hyperalgesia level;Ramsay sedation score;awakening time;Extubation time;Sleep rhythm;Remifentanil dosage;qCON and qNOX;QoR-15 score;Patient and investigator satisfaction;zinc level; | — |
Countries
China
Contacts
Public ContactLi Yize
Tianjin Medical University General Hospital
Outcome results
None listed