Zoster associated pain
Conditions
Interventions
2:Ultrasound-guided targeted injection methylcobalamin
1:oral methylcobalamin+Ultrasound-guided targeted injection Lidocaine
Sponsors
Shanghai Tenth People's Hospital, Affiliated Tenth People's Hospital of Tongji University
Eligibility
Sex/Gender
All
Age
50 Years to 72 Years
Inclusion criteria
Inclusion criteria: Patients were included in this study on the basis of the following criteria: a confirmed diagnosis of HN lasting for at least 15-180 days, older than 50 yrs, experienced cutaneous and/or subcutaneous pain of the dermatomal area or adjacent cutaneous dermatomes temporally and spatially associated with their HZ rash, and a worst pain score of 4 or greater on an 11-point NRS in the past 24 hrs.
Exclusion criteria
Exclusion criteria: Subjects who met the following criteria were excluded from this study: unilateral dermatomal pain in the vesicular region for less than 120 days with diffusely distributed neuropathic pain or significant pain outside the target regions; any clinically significant medical condition or laboratory abnormality; any cognitive impairment; and cardiac pacemakers, severe general diseases, hypersensitivity to cobalamin, or use of any topical analgesic or nerve blocker within 10 days before the baseline visit. Although the use of topical analgesics was considered an exclusion criterion, patients were allowed to continue oral analgesics that they had previously taken for pain control at the same dose. No change of medications was permitted, but dose reduction or complete discontinuation of analgesics was allowed during the course of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain intensity;pain intensity; | — |
Secondary
| Measure | Time frame |
|---|---|
| e Patients’ Global Impression of Change (PGIC) scale;ADL and health-related QoL;QST;Sensory conduction of Ad fibers;pain evoked potentials of Ad fibers; | — |
Countries
CHINA
Contacts
Public ContactGang Xu
Affiliated Tenth People's Hospital of Tongji University
Outcome results
None listed