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A clinical study of mini-invasive vascular interventional surgery for refractory hepatic encephalopathy

A clinical study of mini-invasive vascular interventional surgery for refractory hepatic encephalopathy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200064205
Enrollment
Unknown
Registered
2022-09-30
Start date
2022-09-30
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver cirrhosis

Interventions

surgery group:vascular interventional surgery
Control group:treat with lactulose

Sponsors

West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 75 years; 2. Cirrhosis with refractory hepatic encephalopathy; 3. Presence of spontaneous portosystemic shunt with the diameter > 10cm.

Exclusion criteria

Exclusion criteria: 1. Previous treatments with TIPS or surgical shunt; 2. Child-Pugh score > 9; 3. Previous esophageal-gastric varices bleeding or refractory ascites; 4. Prescribed with antibiotics or lactulose within 4 weeks before enrollment; 5. Vital organ insufficiency (heart, lung, kidney, brain, etc.); 6. Presence of HCC beyond Milan criteria or other malignancy; 7. Residency in high altitudes (higher than 2500 meters above the sea level); 8. In pregnancy or lactation;

Design outcomes

Primary

MeasureTime frame
Hepatic encephalopathy;—

Secondary

MeasureTime frame
Biochemical and metabolic variables, etc;Death, liver transplantation, and other liver cirrhosis complications;—

Countries

China

Contacts

Public ContactHao Wu

West China Hospital, Sichuan University

594264513@qq.com18980601287

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026