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Establishment and validation of biomarker combination model for predicting the efficacy of PD-1 in patients with advanced non-small cell lung cancer

Establishment and validation of biomarker combination model for predicting the efficacy of PD-1 mAb in patients with advanced non-small cell lung cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200064180
Enrollment
Unknown
Registered
2022-09-29
Start date
2022-09-30
Completion date
Unknown
Last updated
2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

No:No available (observational)

Sponsors

Peking University Shenzhen Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. NSCLC was diagnosed according to WHO classification guidelines for lung tumors (4th Edition); 2. Advanced stage(IIIA-IVB according to the 8th edition of International Association for the study of Lung Cancer TNM; 3. Patients using PD-1 monoclonal antibody alone or in combination (such as combined anti angiogenic drugs and chemotherapy); 4. All patients were treated with PD-1 monoclonal antibody >= 1 time, and the therapeutic effect could be evaluated; 5. Complete follow-up data shall be available during the follow-up (the follow-up shall be conducted by telephone, and the patients shall be informed of the contents of the study orally. The follow-up data of the patients can be included in the study only after the informed consent of the patients or their families is obtained.

Exclusion criteria

Exclusion criteria: 1. Pathology contains small cell lung cancer; 2. Other malignant tumors occurred or currently combined within 5 years; 3. Patients with severe liver and kidney function or other organ injuries before treatment; 4. PS > 3, unable to tolerate immunotherapy; 5. The clinical data are seriously incomplete.

Design outcomes

Primary

MeasureTime frame
PFS;OS;irAEs;

Countries

china

Contacts

Public ContactXu Ping

Peking University Shenzhen Hospital

799721206@qq.com+86 13510331460

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026