heparin anticoagulation in Critically Ill Patients with CRRT
Conditions
Interventions
Heparin Loading Test (HLT) anticoagulation protocol:HLT protocol using the relationship between the activated partial-thromboplastin time (aPTT) after heparin loading test and the heparin maintain dos
Conventional heparin group:2500u loading dose of heparin,3ml/h maintenance dose of heparin antcoagulation
Sponsors
Dalian Municipal Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged > 18 years; 2. Heparin anticoagulation for Critically Ill Patients in CRRT; 3. Patients and/or family members agree to participate in the clinical trial and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Use of other anticoagulant drugs for 24h and/or recent (7 days) use of antiplatelet drugs; 2. High blood risk, such as active gastrointestinal ulcers, congenital or acquired bleeding abnormalities (platelet count < 50 x 10^9/L), a history of intracranial bleeding, moderate or severe stroke within the past 6 months, and major surgery or trauma within the last 30 days; 3. Patients with liver failure; 4. Have mental illness cannot cooperate; 5. Allergic to heparin or history of thrombocytopenia caused by heparin; 6. Pregnant, recently pregnant, nursing women; 7. Contraindications to anticoagulant therapy; 8. Have participated in another drug/device study or are in the follow-up period of another drug/device study. 9. The researchers concluded that there were other conditions that were not suitable for inclusion; 10. Excluded patients were those who received UFH for less than 6 hours or without an APTT at 6 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Initial perfusion rate (units/kg/h);Blood clot routine;Time required to achieve threshold aPTT (h);Percentage achieving threshold aPTT;lifetimes of filters; | — |
Countries
China
Contacts
Public ContactShan Liu
Dalian Municipal Central Hospital
Outcome results
None listed