General anesthesia for non-cardiac surgery
Conditions
Interventions
Experimental group:Inhalation of hydrogen gas
Control group:No inhalation of hydrogen
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1. Patient aged >= 45 years, regardless of gender; 2. Patients intended to undergo elective or emergency non-cardiac surgery under general anaesthesia; 3. Proposed abdominal, orthopaedic or vascular surgery with an operative time of 1 h-4 h; 4. Satisfy any 1 of the following 5 criteria: (1) History of coronary heart disease, including angina pectoris; (2) History of stroke; (3) Undergoing vascular surgery; (4) History of peripheral arterial disease; (5) Any 2 of the following 8 criteria: 1) Acute surgery; 2) History of smoking; 3) History of hypertension; 4) History of diabetes mellitus; 5) History of transient ischaemic disease; 6) Plasma creatinine > 175 µM; 7) Aged 70 years or older; 8) History of congestive heart failure.
Exclusion criteria
Exclusion criteria: 1. Pregnancy; 2. Unable to give informed consent prior to surgery; 3. No preoperative oxygen supplementation and a peripheral oxygen saturation (SpO2) of less than 90%; 4. Drug allergy involving any interventional drug; 5. Surgical treatment within 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Troponin level;Incidence of myocardial injury after non-cardiac surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality rate;Non-fatal myocardial infarction;Symptoms of myocardial ischemia;Non-fatal serious adverse events;Surgical site infection;pneumonia;Sepsis;Abnormal liver function;Renal insufficiency;Incidence of postoperative delirium;Postoperative hospital stay;ICU stay time;H-FABP; | — |
Countries
China
Contacts
Public ContactLi Yize
Tianjin Medical University General Hospital
Outcome results
None listed