Rheumatoid arthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients who meet the classification criteria of rheumatoid arthritis jointly formulated by ACR/EULAR in 2010; 2. Patients who meet the diagnostic criteria for knee osteoarthritis formulated by the Orthopedic Branch of the Chinese Medical Association in 2010; 3. Aged 18-60 years.
Exclusion criteria
Exclusion criteria: 1. Severe infection history in the last month; 2. Patients with severe diseases of respiratory system, cardiovascular system, digestive system, urinary system, blood system and other important organs, as well as severe extraarticular manifestations such as constrictive pericarditis, vasculitis, secondary Sjogren's syndrome and other patients requiring glucocorticoids; 3. Overlapping syndromes with other rheumatic diseases; 4. Patients with HIV infection and malignant tumor; 5. Pregnant and lactating women, women with family planning and mental patients; 6. Patients who are allergic to lidocaine or cannot be treated by intramuscular minimally invasive therapy; 7. Does not meet the above diagnostic criteria; Patients without informed consent; Patients who may not be able to complete the whole process of this study; The investigator considers it inappropriate to conduct this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Erythrocyte sedimentation rate;C-reactive protein;Inflammatory cytokines;rheumatoid factor;Immunohistochemistry;VAS;Synovial scoring under microscope; | — |
Countries
China
Contacts
Department of Chinese Medicine and Rheumatology, General Hospital of Southern Theatre Command, Peoples R China