Urothelial carcinoma
Conditions
Interventions
patients were classified as non-neoplastic diseases if none of the promoter regions are methylated.
Index test:Urine DNA methylation: Patients are classified as urothelial carcinoma if at least one promoter region of 15 specified sites are methylated
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: The experimental group: Patients who were initially diagnosed with urothelial carcinoma by clinical imaging (CT or MRI), and planned to undergo surgical treatment, and were finally confirmed as urothelial carcinoma by postoperative pathology. The control group: Non-neoplastic diseases of the urinary system were excluded clinically (imaging and blood tumor markers ).
Exclusion criteria
Exclusion criteria: The experimental group: 1. Patients had contraindications for surgery; 2. Patients had a history of bladder cancer, prostatecancer, or other malignant tumors of the urinary system; 3. Patients planned to undergo radical bladder resection in the short term and could not complete the follow-up study; 4. Patients refused to sign the informed consent and participate in this clinicalstudy. The control group: 1. Patients had a history of bladder cancer, prostate cancer, or other malignant tumors of the urinary system; 2. Patients refused to sign the informed consent and participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Specificity;Positive predictive value;Negative predictive value;Overall consistency; | — |
Countries
China
Contacts
Public ContactZhou Liqun
Peking University First Hospital
Outcome results
None listed