Esketamine opioid-free intravenous anesthesia versus opioid intravenous anesthesia in spontaneous ventilation video-assisted thoracic surgery: a randomized control trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200064152

Enrollment

Unknown

Registered

2022-09-28

Start date

2022-09-15

Completion date

Unknown

Last updated

2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pulmonary nodule

Interventions

opioid-free group:Esketamine replaces opioids

opioid group:opioid

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing thoracoscopic surgery under general anesthesia in our hospital from 2022-9-15 to 2022-11-15 (single or multiple wedge resection) were selected; 2. Aged 18-64 years; 3. BMI was 16-25 kg/m2; 4. They could communicate normally and cooperate with pain score; 5. Signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Previous history of thoracic surgery; 2. Reoperation on the ipsilateral side during the study period; 3. Uncontrolled hypertension, coronary heart disease, hepatorenal insufficiency; 4. Uncontrolled hyperthyroidism; 5. Visual impairment; 6. Allergy to research drugs; 7. Mental illness; 8. Severe cardiopulmonary dysfunction; 9. History of chronic pain or regular use of opioids.

Design outcomes

Primary

Measure	Time frame
NRS;	—

Secondary

Measure	Time frame
Spontaneous ventilation recovery time;Hemodynamic index;Respiratory parameter index;Incidence of physical and choking cough;Arterial blood gas analysis;Opioid dosage;Dosage of vasoactive drugs;Awakening time;Complication;	—

Countries

China

Contacts

Public ContactLan Lan

The First Affiliated Hospital of Guangzhou Medical University

Vapour2046@126.com02083062938

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026