Critically Ill patients with venous thromboembolism
Conditions
Interventions
heparin anticoagulant for Critically Ill Patients with Venous thromboembolism:The multiple of APTT defined as the ratio of the activated partial-thromboplastin time (aPTT) after 10mg heparin loading t
Sponsors
Dalian Municipal Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged > 18 years; 2. Meet the diagnostic criteria for symptomatic deep vein thrombosis (ultrasound examination), involving the femoral vein or iliac vein; 3. Hemodynamically-stable pulmonary embolism (PE); 4. Patients and/or family members agree to participate in the clinical trial and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Use of other anticoagulant drugs for 24 h and/or recent (7 days) use of antiplatelet drugs; 2. High blood risk, such as active gastrointestinal ulcers, congenital or acquired bleeding abnormalities (platelet count < 50 x 10^9/L), a history of intracranial bleeding, moderate or severe stroke within the past 6 months, and major surgery or trauma within the last 30 days; 3. Patients with liver failure 4. Have mental illness cannot cooperate; 5. Allergic to heparin or history of thrombocytopenia caused by heparin; 6. Pregnant, recently pregnant, nursing women; 7. Contraindications to anticoagulant therapy; 8. Have participated in another drug/device study or are in the follow-up period of another drug/device study; 9. The researchers concluded that there were other conditions that were not suitable for inclusion; 10. Excluded patients were those who received UFH for less than 6 hours or without an APTT at 6 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| APTT;The multiple of APTT defined as the ratio of the activated partial-thromboplastin time (aPTT) after 10mg heparin loading test to the aPTT on admission.;maintenance dose of heparin for efficient anticoagulation; | — |
Countries
China
Contacts
Public ContactShan Liu
Dalian Municipal Central Hospital
Outcome results
None listed