Depression
Conditions
Interventions
group1:Transcranial Stimulation on M1
group2:Transcranial Stimulation on DLPFC
group3:Sham Stimulation
Sponsors
Wuxi Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Diagnostic criteria that meet the ICD-10 diagnostic criteria for depressive disorder; 2. The Hamilton Depression Scale (L7-item version) score >= 8; 3. Aged 18-75 years with more than 5 years of formal education; 4. All participants signed a informed consent. 5. Right-handedness, determined by Edinburgh Handedness Scale; 6. With somatic pain symptoms and is currently experiencing pain of any kind.
Exclusion criteria
Exclusion criteria: 1. Prior medical history of central nervous system disease, severe head injury, active or progressive neurodegenerative disease or physical disease and/or other severe medical conditions; 2. History of electroconvulsive therapy within the last six months; 3. Substance abuse or dependence; 4. Comorbidities associated with other sleep disorders (e.g., sleep apnea) or worked a night shift or had a rotating work schedule within the last three months; 5. With MAOI within four weeks; 6. Pregnant and lactation; 7. Recent use of antibiotics or probiotic synbiotics within 30 days of study participation; history of gastrointestinal surgery or severe congenital abnormalities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Short-form of Mc Gill pain questionnaire;Hamilton Depression Scale;Hamilton Anxiety Scale;Polysomnography;Electroencephalogram;Somatic Self-rating Scale;Gastrointestinal Symptom Rating Scale;tDCS Adverse Effects Questionnaire;Pittsburgh Sleep Quality Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| BMI-based Silhouette Matching Test;Temporal Experience of Pleasure Scale; Dimensional Anhedonia Rating Scale;Snaith-Hamilton pleasure scale;Acceptance and Ac-tion Questionnaire-2nd Edition;Connor-Davidson resilience scale;Childhood Trauma Questionnaire;Cognitive Flexibility Inventory;Emotion Regulation Questionnaire;The Epworth Sleeping Scale;Insomnia Severity Index;Properties of the Body Perception Questionnaire-Short Form;The Depression Anxiety Stress Scale;fatigue severity scale;Bech-Rafaelsen Mania Rating Scale;Columbia-Suicide Severity Rating Scale;Multidimensional Dream Inventory;Nightmare Distress Questionnaire ;dream recall frequency; | — |
Countries
China
Contacts
Public ContactQi Zhang
Wuxi Mental Health Center
Outcome results
None listed