Septic Shock
Conditions
Interventions
Sublingual microcirculation group:sublingual microcirculation monitoring
EGDT group:Early goal-directed fluid resuscitation therapy
Sponsors
The Second People’s Hospital of Shenzhen
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 85 years; 2. Meet the diagnostic criteria for Septic Shock: (1) Meeting the definition of sepsis 3.0: sepsis is defined as life-threatening organ dysfunction due to a dysregulated host response caused by infection, i.e. infection (clinical diagnosis) + SOFA >= 2 points; (2) Combined persistent hypotension, requiring vasoactive agents to maintain MAP >= 65 mmHg despite adequate fluid resuscitation; 3. Compliance with the Declaration of Helsinki and Chinese regulations for clinical trial studies, and informed and consenting participation by the patient or his/her family.
Exclusion criteria
Exclusion criteria: 1. Pregnant, persistent epilepsy, acute haematological malignancies, advanced tumours, pulmonary oedema, persistent asthma, severe acute respiratory distress syndrome, malignant cardiac arrhythmias, structural cardiac abnormalities (e.g., severe valvular disease, atrial septal/ventricular septal defects) and other conditions where there is a contraindication to treatment or potential to affect haemodynamic status; 2. Those with cardiogenic shock, haemorrhagic shock and other types of shock; 3. Those requiring emergency surgical treatment; 4. The presence of contraindications to the placement of a central venous catheter; 5. The presence of tongue injury, inflammation and other conditions affecting sublingual microcirculation monitoring; 6. Abandonment of continued treatment; 7. Those who, in the opinion of the investigator, are not suitable for inclusion in the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Variation of Sequential Organ Failure Score in 72 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day mortality;Total 24-hour fluid intake;Length of ICU stay; | — |
Countries
China
Contacts
Public ContactZhe Deng
The Second People’s Hospital of Shenzhen
Outcome results
None listed