Effect of a1-adrenergic receptor agonists on high risk factors of perioperative stroke

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200064137

Enrollment

Unknown

Registered

2022-09-27

Start date

2022-09-13

Completion date

Unknown

Last updated

2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

perioperative stroke

Interventions

experimental group:Continuous pump injection of norepinephrine by 0.01~0.03 µg(kg·min)

Control group:Continuous pump injection of physiological saline solution by 0.01~0.03 µg(kg·min)

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged >= 65 years; 2. ASA grade II/III; 3. Preoperative blood routine, coagulation function, liver and kidney function are normal; 4. The estimated operation time is 2 ~ 4 hours; 5. Estimated bleeding volume < 500 ml.

Exclusion criteria

Exclusion criteria: 1. Dysfunction of heart and lung; 2. Previous history of cerebrovascular disease; 3. Cognitive impairment caused by dementia or other reasons; 4. History of mental illness, alcoholism and drug abuse.

Design outcomes

Primary

Measure	Time frame
vWF;FIB;TAT;D-dimer;S-100ß protein;NSE;MMSE;Number of stroke patients;	—

Secondary

Measure	Time frame
dosage of norepinephrine;	—

Countries

China

Contacts

Public ContactShan Zhang

The Second Hospital of Hebei Medical University

zhang18531135269@126.com15803215850

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026