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Comparison of the effects of intravenous oxycodone and lidocaine combined with penehyclidine hydrochloride intravesical instillation on catheter-related bladder irritation

Comparison of the effects of intravenous oxycodone and lidocaine combined with penehyclidine hydrochloride intravesical instillation on catheter-related bladder discomfort: a prospective randomized control double-blind study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200064136
Enrollment
Unknown
Registered
2022-09-27
Start date
2022-09-28
Completion date
Unknown
Last updated
2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Catheter-related bladder discomfort

Interventions

Group A:Intravenous Oxycodone Hydrochloride Injection
Group B:Intravesical infusion of lidocaine and penehyclidine hydrochloride

Sponsors

China-Japan Union Hospital of Jilin University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
16 Years to 69 Years

Inclusion criteria

Inclusion criteria: 1. Male, aged 18-69 years, ASA I-II grade; 2. Non-urological surgery patients; 3. Patients who complained of CRBD after surgery; 4. There are no contraindications to lidocaine, penehyclidine and oxycodone.

Exclusion criteria

Exclusion criteria: 1. Multiple catheterization failures; 2. Bladder outflow tract obstruction, benign prostatic hyperplasia, neurogenic bladder; 3. Overactive bladder (nocturia 3 times, or voiding >8 times in 24 hours); 4. Cognitive dysfunction or communication impairment; 5. Combined with serious heart, brain, lung, liver and kidney diseases.

Design outcomes

Secondary

MeasureTime frame
delirium;dry mouth;respiratory depression;—

Primary

MeasureTime frame
CRBD severity score;Ramsay sedation score;Urethral NRS score;urine output;—

Countries

China

Contacts

Public ContactPeng Chen

China-Japan Union Hospital of Jilin University

cpeng@jlu.edu.cn13596066218

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026