gastroesophageal reflux disease
Conditions
Interventions
experimental group:peroral endoscopic cardiac constriction
Control group:proton pump inhibitors
Sponsors
The First Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years; 2. Classic symptoms of reflux or heartburn; 3. Esophageal impedance pH monitoring showed abnormal acid reflux; 4. Esophageal manometry showed normal or subnormal lower esophageal sphincter pressure; 5. Endoscopically confirmed normal or mild esophagitis (LA grade A/B) cardia relaxation; 6. No proton pump inhibitors and other drugs affecting gastrointestinal motility were taken within 2 weeks before enrollment.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of endoscopic or surgical anti-reflux surgery; 2. Hiatal hernia diameter greater than 2 cm; 3. Patients with Barrett's esophagus or esophageal cancer diagnosed by pathological biopsy; 4. Other esophageal esophagus Patients with movement disorders; 5. Heart, lung, liver and kidney functions are not acceptable for surgery; 6. Patients with active infection or serious systemic diseases; 7. Patients with severe coagulation disorders; 8. Pregnant patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gastroesophageal reflux disease-health related quality of life (GERD-HRQL) score;gastroesophageal reflux disease questionnaire (GERD-Q) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| DeMeester Score;Esophageal pH;Salivary pepsin;Gastroscopy;Adverse events; | — |
Countries
China
Contacts
Public ContactZhe Shen
The First Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed