Platelet transfusion refractoriness, PTR
Conditions
Interventions
Test Group and Control Group:HLA Epitope matching and traditional antigen matching
Sponsors
The Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: Ineffective Platelet Transfusion (PTR) means that the clinical bleeding and platelet count are not improved and obviously lower than expected after two or more ABO-identical platelet transfusions with less than 5 days preservation time. Study participants: PTR patients aged 16-65 years who were thrombocytopenia with alloimmune aplastic anemia, myelodysplastic syndrome, or acute myeloid leukemia (AML) , it was not effective for random donor platelet transfusion, and HLA antibody screening test was positive. Platelet infusions with HLA Matchmaker epitope matching (Hem) were selected using HLA Matchmaker epitope matching (especially small fragments) . Platelet transfusions of Hla epitope-matched (Hem) or traditional HLA antigen-matched platelets were provided in random order per hospitalization cycle in patients with immune PTR, and the primary outcome was to observe changes in the platelet increase index (1HPCI) 1 hour after transfusion in patients with PTR.
Exclusion criteria
Exclusion criteria: 1. Patients with Splenomegaly; 2. Patients recently treated with Antithymocyte Globulin; 3. Pregnant or lactating women; 4. Patients who were unable to give informed consent or comply with the trial protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PCI; | — |
Secondary
| Measure | Time frame |
|---|---|
| 1 h CCI, 24 h CCI; | — |
Countries
China
Contacts
Public ContactWu Changlin
The Shenzhen Second People's Hospital
Outcome results
None listed