Major Depressive Disorder
Conditions
Interventions
Really stimulate group:Transcranial Alternating Current Stimulation
shame stimulate group:shame stimulate
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. All patients with depressive Disorders are required to meet the Diagnostic criteria for depressive disorders-depressive episode in the Diagnostic and Statistical Manual of Mental Disorders, Fifth edition (DSM-V) issued by the American Psychiatric Association. In other words, they have to show at least five of the following nine symptoms for two weeks: (1) Persistent depression for more than two weeks; (2) Loss of interest/pleasure in all activities; (3) Significant weight loss or weight gain without dieting (e.g. weight change of more than 5% of original body weight within a month) or loss of appetite or weight gain almost daily; (4) Insomnia or excessive sleep almost every day; (5) Psychomotor agitation or retardation; (6) Fatigue or lack of energy almost every day; (7) Feeling worthless, or excessive or inappropriate feeling of guilt, self-blame, or self-delusion; (8) Decreased ability to think or concentrate or hesitate; (9) Recurrent thoughts of death, recurrent suicidal ideation without specific plans, or suicide attempts, or suicidal behavior. The first and second terms are the conditions that must be satisfied. 2. Aged 18 and 65 years; 3. Non-comorbidity of other mental diseases; 4. Right-handed; 5. Patients who did not receive medication 4 weeks before enrollment, or took antidepressant drugs stably for more than 4 weeks; 6. 24 items of Hamilton Depression Scale score >= 20 points; 7. The audiovisual level is sufficient to complete the examination required for the study; 8. Informed consent signed by patients or family members.
Exclusion criteria
Exclusion criteria: 1. Drug or alcohol abuse or dependence within 6 months before enrollment; 2. Had suffered from other mental diseases within 6 months before enrollment; 3. Severe or unstable organic diseases; 4. Scores of item 3(suicide item) in 24 items of Hamilton Depression Scale >= 3; 5. Hamilton Depression Scale score of 14 items was higher than Hamilton Depression scale score of 24 items; 6. A history of cochlear implantation, pacemaker implantation, or implantation of any brain device; A history of previous brain surgery or epilepsy; 7. Pregnant or lactating women; 8. The skin integrity of the electrode placement site is damaged or allergic to electrode gel or adhesive; 9. Participated in any other clinical trial within 1 month before enrollment; 10. The researcher considers that it is not appropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale-17, HAMD-24; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale, HAMA;Montgomery–Asberg Depression Rating Scale, MADRS;Pittsburgh Sleep Quality Index, PSQI;22-item Ruminative Responses Scale, RRS;Functional magnetic resonance imaging;Transcranial magnetic stimulation synchronous electroencephalogram; | — |
Countries
China
Contacts
Public ContactYuping Wang
Xuanwu Hospital Capital Medical University
Outcome results
None listed