Type 2 diabetes
Conditions
Interventions
Intervention group:Powder (including 10 ^ 10 CFU/bag of intestinal functional bacteria preparation), oral twice a day (after breakfast and dinner), one bag each time
control group:placebo
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Voluntary participation in this clinical trial; 2. Aged 18-75 years; 3. BMI >= 24 kg/m2, waist circumference >= 80 cm (female), waist circumference >= 90 cm (male); 4. Type 2 diabetes that meets the diagnostic criteria of diabetes in the Chinese Medical Association's 2020 edition of China's guidelines for the prevention and treatment of type 2 diabetes, and does not use any hypoglycemic drugs in the past three months, only diet and exercise control blood sugar, and HbA1c < 7.5%.
Exclusion criteria
Exclusion criteria: 1. Oral drugs such as antibiotics, glucocorticoids, GLP-1 and GLP-1 analogues in recent 3 months; Subjects who received intramuscular or intravenous systemic administration, non gastrointestinal administration or intra-articular administration in the last 3 months; 2. Those who have taken yogurt, probiotics and probiotics in recent 3 months; 3. Have a history of abuse of psychoactive substances; 4. Severe hepatic and renal insufficiency; 5. Chronic gastrointestinal diseases, gastrointestinal diseases that cause various acute and chronic diarrhea or severe constipation; 6. Smoking history > 10 years; 7. Daily consumption of alcohol > 30 g; 8. Serious diseases such as severe anemia, neutropenia, heart failure, organic heart disease, hepatitis B, cirrhosis, kidney disease, infection, and malignant tumor; 9. Pregnant or lactating women, or planned pregnancy in the next 6 months; 10. Nervous system diseases: such as Alzheimer's disease, stroke, Parkinson's disease; 11. Participate in other clinical trials in the past 6 months; 12. Mental diseases: such as schizophrenia, bipolar disorder; 13. Those who have undergone digestive tract surgery within one year or other non digestive tract surgery within half a year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glucose tolerance;obesity improvement;intestinal symbiotic bacteria homeostasis.; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure;blood lipid;uric acid;hormone level;visceral fat;vascular endothelial function; | — |
Countries
China
Contacts
Public ContactWeng Jianping
Outcome results
None listed