Acute Respiratory Distress Syndrome
Conditions
Interventions
control:No
sivillistat sodium group:Sivillistat sodium is inistered
Sponsors
Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 and 90; 2. Patients admitted to ICU due to high risk factors of ALI/ARDS (pneumonia, aspiration, physical and chemical factors, sepsis, pancreatitis, etc.) with oxygenation index of 200-400mmHg; 3. Consistent with the diagnosis of systemic inflammatory response syndrome (SIRS) : body temperature >38? or 90 times/min; Breathing > 20 beats/min or hyperventilation,PaCO212×109/L or 10%; 4. Serum IL-6 or CRP was higher than normal; 5. X-ray chest film generally increased density in both lung fields, decreased brightness, increased and thickened lung texture, scattered patchy shadows of increased density, namely diffuse lung infiltration shadow
Exclusion criteria
Exclusion criteria: 1. Age90-year old; 2. Endotracheal intubation or tracheotomy has been performed; 3. Allergic to sivillistat sodium; 4. Patients with chronic obstructive pulmonary disease, bronchial asthma and myasthenia gravis; 5. Severe liver and kidney failure; Severe hemodynamic instability; Severe heart block or cardiac insufficiency; 6. Patients deemed unsuitable by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Utilization rate of mechanical ventilation;Incidence of severe ARDS; | — |
Secondary
| Measure | Time frame |
|---|---|
| SOFA score;APACHE ? score;white blood cell count;red blood cell count;hemoglobin;blood platelet count;urea;creatinine;bicarbonate radical;eGFR;alanine transaminase;glutamic oxalacetic transaminase;total protein;albumin;globulin;total bilirubin;direct bilirubin;indirect bilirubin;alkaline phosphatase;? glutamyl transpeptidase;total cholesterol;lactic dehydrogenase;thrombin time;prothrombin time;activated partial thromboplastin time;fibrinogen;procalcitonin;Interleukin 6;APACHE ? score;SOFA score;CPOT score;RASS score;arterial pressure;heart rate;respiratory rate;oxygen index;temperature;CRP; | — |
Countries
China
Contacts
Public ContactWei Zhu
Outcome results
None listed