Effect of Low-Dose Norepinephrine Combined with Goal-Directed Fluid Therapy on Postoperative Pulmonary Complications in Thoracic Surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200064081

Enrollment

Unknown

Registered

2022-09-26

Start date

2022-09-30

Completion date

Unknown

Last updated

2024-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thoracic Surgery

Interventions

Group N:Goal-directed fluid therapy combined with low dose norepinephrine

Group G:Goal-directed fluid therapy

Conrol group:Conventional liquid therapy

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective thoracoscopic selective pulmonary parenchymal resection; 2. American Society of Anesthesiologists (ASA) I-III, aged >= 18 years, BMI 18-30 kg/m2, both sexes; 3. No metastasis; 4. Voluntary subjects signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Heart failure, New York Heart Function class > II; 2. Patients with a history of myocardial infarction, myocarditis and hypertrophic cardiomyopathy; 3. History of arrhythmia or antiarrhythmic drug therapy; 4. AV block; 5. Severe liver and kidney insufficiency; 6. History of taking irreversible non-selective monoamine oxidase inhibitors within 2 weeks.

Design outcomes

Primary

Measure	Time frame
Postoperative Pulmonary Complications;	—

Secondary

Measure	Time frame
Oxygenation changes during one-lung ventilation;Hemodynamic changes during one-lung ventilation;Changes in respiratory mechanics during one-lung ventilation;Postoperative pain score;hospital stays;	—

Countries

China

Contacts

Public ContactLijian Chen

The First Affiliated Hospital of Anhui Medical University

chenlijian77@126.com+86 139 6669 9467

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026