aging
Conditions
Interventions
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Sign written informed consent are from the subjects prior to any examination, sampling or analysis the data 2. aged 18-20 years and 75-85 years 3. Patients to be subjected to Single-shot spinal anaesthesia (SSS) or combined spinal-epidural (CSE) anaesthesia 4. ASA Classification ?-?
Exclusion criteria
Exclusion criteria: 1. Patients with mental, neurological diseases, or cognitive dysfunction 2. Patients taking sedation, analgesia and psychotropic drugs for a long time 3. Patients with metabolic and autoimmune diseases 4. Chronic alcohol or drug users 5. Neuromuscular diseases (specifically, truncation, myasthenia gravis) 6. Patients with spinal trauma or severe lumbar pain, severe systemic infection or lumbar infection 7. Combined with heart disease (pacemaker placement, frequent arrhythmia, atrial fibrillation, etc.) and lung disease (lung infection, emphysema, chronic complicating lung disease, etc.) 8. Impairment of liver and kidney function (ALT and/or AST >1.5 times the normal range, BUN and/or Cr>Upper limit of normal) 9. Patients with preoperative coagulopathy (PT/APTT above the upper limit of the reference value), recent or long-term use of anticoagulant or antiplatelet agents 10. Patients who did not sign the informed consent form or who refused to participate in the clinical trial after signing the informed consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| metabonomics;proteomics; | — |
Countries
China
Contacts
Public ContactZongze Zhang
Zhongnan Hospital of Wuhan University
Outcome results
None listed