chronic kidney diseases
Conditions
Interventions
Group 1:Irbesartan+prednisone
Sponsors
The Second Affiliated Hospital of the Amy Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Renal biopsy was pathologically diagnosed as IgAN and the crescent score was C1 (1 = crescent 1.0g/24 hour (or PCR > 1.0g/g) was measured twice in a week.
Exclusion criteria
Exclusion criteria: 1.Secondary IgAN: secondary IgAN caused by systemic diseases such as systemic lupus erythematosus(SLE), congenital purpura and liver cirrhosis. 2.Hepatitis B virus carriers and other chronic liver diseases. 3.All IgAN patients confirmed by biopsies in the study had negative levels of autoimmune antibodies (such as ANA, anti-dsdna, anti-ENA and anti-smith) and were not diagnosed with systemic lupus erythematosus (SLE) according to the guidelines of the American Society of Rheumatology. 4.HIV infection. 5.The patient participates in any other study and has received another research drug or intervention treatment (within the first month before signing the informed consent form). 6.Suspected or known allergy to corticosteroids or irbesartan. 7.Patients who were treated with corticosteroids or irbesartan within the first three months, or with other immunosuppressants or any other biological agents within six months before screening; patients who did not respond to previous immunosuppressants. 8.Women who are positive for pregnancy tests during screening or lactation, or who plan to conceive within 24 months, or who are reluctant to use contraceptive methods throughout the study. 9.Individuals or legal guardians / representatives are unable or unwilling to provide written informed consent. 10.Currently dependent on drug or alcohol use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A 50% drop in eGFR; | — |
Secondary
| Measure | Time frame |
|---|---|
| End-stage renal disease;Urinary protein remission; | — |
Countries
China
Contacts
Public ContactZhao Jinghong
The Second Affiliated Hospital of the Amy Medical University
Outcome results
None listed