Esophageal cancer
Conditions
Interventions
Control group:Sedation under general anesthesia was done by intravenous propofol
Experimental group:Sedation under general anesthesia was done by intravenous remimazolam
Sponsors
Affiliated Cancer Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Select patients undergoing thoracoscopic laparoscopy combined with radical esophagectomy under general anesthesia; 2. Gender is not limited; 3. Aged 40 to 75 years; 4. ASA I-II grade.
Exclusion criteria
Exclusion criteria: 1. Severe liver and kidney dysfunction;2. Neurological diseases;3.Severe cardiopulmonary insufficiency;4.Preoperative pulmonary infection was confirmed;5.acid-base disturbance;6.Preoperative radiotherapy, chemotherapy and blood transfusion were performed;7.Patients with hypertension that cannot be controlled by drugs;8.Patients with diseases of endocrine system;9.Patients with a history of drug allergy and dependence;10.The patient refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The concentrations of cortisol, epinephrine (E) and norepinephrine (NE) in plasma and TNF-a, IL-6 and IL-10 in serum at different times during operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| SBP, DBP, HR and SpO2 at different points during operation;The time to stop intravenous anesthesia infusion until eye opening and the time to stop intravenous anesthesia infusion until extubation;PaCO2 index of arterial blood gas in spontaneous breathing before and after extubation;RS score and Ramsay sedation score;The occurrence of adverse reactions such as agitation, choking, nausea and vomiting, decreased blood pressure and respiratory depression during extubation.; | — |
Countries
China
Contacts
Public ContactLyu Shuaiguo
Affiliated Cancer Hospital of Zhengzhou University
Outcome results
None listed