Chronic sinusitis
Conditions
Interventions
Control group:controlled hypotension
Experimental group:Protective hypotension
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years, both sexes; 2. Patients diagnosed with chronic sinusitis, with or without nasal septum deviation, with or without nasal polyps, with or without turbinate hypertrophy, with or without nasal mass, and planned to undergo nasal endoscopic sinus surgery to relieve nasal obstruction; 3. ASA classification I-II; 4. Volunteer to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Contraindications of controlled hypotension include hypovolemia and severe anemia, substantial lesions and dysfunction of vital organs, vascular lesions, and significant insufficiency of oxygen transport capacity of tissues and organs; 2. Preoperative coagulation dysfunction; 3. History of mental illness or cognitive impairment; 4. BMI is too high (> 30 kg/m2) or too low (< 18 kg/m2); 5. Patients with grade 2 or above hypertension, and patients with grade 1 hypertension whose preoperative blood pressure control is not ideal; 6. Allergic to intraoperative drugs; 7. Pregnant women; 8. Take any medication before operation that may affect the outcome and safety during operation; 9. Opioid dependence or opioid tolerance; 10. The investigator deemed it inappropriate to participate in the clinical trial.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative blood loss;Blood gas parameters;Blood gas parameters;Extubation time;Ramsay sedation score within 5 minutes after extubation;Length of stay in PACU;Incidence of adverse reactions within 24 hours after operation;Mini-mental State Examination score at 24 hours after surgery; | — |
Primary
| Measure | Time frame |
|---|---|
| Boezaart endoscopic field grading; | — |
Countries
China
Contacts
Public ContactTao Meng
Qilu Hospital of Shandong University
Outcome results
None listed