acute postoperative pain
Conditions
Interventions
Experimental group:After successful intubation, before skin incision, esketamine 50mg + normal saline was diluted to 50ml, 0.125ml/kg/h esketamine was given intravenously at a constant rate, and esket
Control group:After successful intubation, an equal volume of normal saline was given by constant-speed pump. After the operation, butorphanol 8mg+NS=100ml, background dose 1.5ml/h, Bolus 1.5ml, inter
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years; 2. ASA ?-? level; 3. BMI >=18.5 and < 30; 4. Laparoscopic gynecological surgery was planned under general anesthesia, including laparoscopic hysterectomy, laparoscopic bimadnexectomy, and laparoscopic hysteromyoma excavation, and was treated with postoperative patient-controlled intravenous analgesia pump (PCIA); 5. Hospital stay longer than 48 hours; 6. Able to read and write; 7. Informed consent can be signed.
Exclusion criteria
Exclusion criteria: 1. Diagnosed mental illness; 2. Unable to communicate before surgery due to cognitive dysfunction or language impairment; 3. A history of chronic pain or opioid abuse before surgery; 4. Postoperative admission to ICU is planned; 5. Laparotomy may be performed during the operation; 6. Patients with preoperative sleep disorder requiring oral medication; 7. A history of drug use and/or alcoholism within the last 3 months, with an average daily consumption of >2 units of alcohol (1 unit =360ml 5% alcohol beer or 45ml 40% alcohol liquor or 150ml wine; 8. Known allergy to esketamine and flurbiprofen ester; 9. Patients with any of the following contraindications for the use of Esketamine injection: (1) Patients at serious risk of elevated blood pressure or intracranial pressure; (2) Patients with high intraocular pressure (glaucoma) or penetrating ocular trauma; (3) Patients with poorly controlled or untreated hypertension (resting systolic/diastolic blood pressure exceeding 180/110mmHg); (4) Untreated or undertreated patients with hyperthyroidism (hyperthyroidism); 10. Patients with any of the following contraindications for flurbiprofen injection: (1) Suffering from severe peptic ulcers; (2) Serious blood diseases; (3) Severe abnormal heart, liver and kidney function; (4) Severe hypertension; (5) History of aspirin asthma or previous history; (6) Eloxacin, lomefloxacin and norfloxacin are being used; 11. Pregnancy or lactation; 12. Participated in clinical research of other drugs or medical devices in the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numerical rating scale (NRS) score at motion at 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score;Ramsay score;St. Mary's Hospital Sleep Score;Hospital Anxiety and Depression Score;QoR-15 Quality of Recovery Score;Satisfaction of patients and their families with postoperative analgesia treatment; | — |
Countries
China
Contacts
Public ContactYang Jianjun
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed