lung disease
Conditions
Interventions
group P:Alfentanil 10ug/kg+Propofol 1.5mg/kg
group R :Alfentanil 10ug/kg+Rimazolam 0.2mg/kg
Sponsors
Department of Anesthesiology, Wuhan No.1 Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who plan to undergo fiberoptic bronchoscopy with spontaneous respiration; 2. Aged 18-65 years, no gender limit; 3. Body mass index (BMI) 18.5~30kg/m^2; 4. American Society of Anesthesiologists (ASA) grade ? to ?; 5. Voluntarily participate and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of serious heart, brain, lung, liver, kidney and metabolic diseases; 2. Patients with a history of recovery from abnormal surgical anesthesia; 3. Electrocardiogram: heart rate 180mmHg and/or diastolic blood pressure >110mmHg in hypertensive patients, or <90/60mmHg in hypotensive patients; 6. Patients with neuromuscular system diseases and mental diseases; 7. Patients with esophageal reflux disease; 8. Suspected abuse of narcotic analgesics or sedatives; 9. Those who predict that difficult airway may occur or have occurred before; 10. Known allergy to emulsions, benzodiazepines and opiates; 11. Participated in other drug trials within three months or was unable to effectively communicate or cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative blood pressure reduction;Vital signs;Validity indicators;Anesthesia effect;Ramsay sedation score;Safety indicators;Satisfaction rating; | — |
Countries
China
Contacts
Public ContactChen Zhijun
Department of Anesthesiology, Wuhan No.1 Hospital
Outcome results
None listed