Late preterm delivery of twins
Conditions
Interventions
Experimental group:Dexamethasone (1 mL:5 mg), intramuscular injection, q12h*4 times
Control group:Normal saline 1mL, intramuscular injection, q12h*4 times
Sponsors
Obstetrics and Gynecology Hospital, Fudan University
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged over 18 years; 2. Twin pregnancy, 34+0 weeks to 36+5 weeks; 3. High risk of preterm birth: premature rupture of membranes before term; Preterm labor (regular contractions: with or without lower abdominal pain, shortened cervical canal, dilated uterine orifice, increased vaginal discharge, redness); Induction of labor or cesarean section within 24 h-7 days of any indication; 4. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Fatal fetal malformation, fetal distress, fetal death in utero; 2. Delivery is expected within 12 hours; 3. Use of corticosteroids within one week or before 34 weeks of gestation; 4. Chorioamnionitis; 5. Steroid drugs should be used for other medical and surgical diseases; 6. Patients with contraindications in steroid drug use.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| neonatal mortality and/or other neonatal morbidities;long-term neurodevelopment; | — |
Primary
| Measure | Time frame |
|---|---|
| severe respiratory complications;perinatal death within the first 72 h of delivery; | — |
Countries
China
Contacts
Public ContactXiong Yu
Obstetrics and Gynecology Hospital, Fudan University
Outcome results
None listed