Post-traumatic osteomyelitis
Conditions
Interventions
case series:N/A
Sponsors
Southern Medical University Nanfang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Voluntarily participate in the study and sign the informed consent; 2. Aged >=18 years, no gender limit; 3. Patients diagnosed with traumatic osteomyelitis; 4. Patients who need to undergo bone infection lesion removal surgery according to the treating doctor's judgment.
Exclusion criteria
Exclusion criteria: 1. Acute osteomyelitis; 2. Systemic and immune diseases; 3. Prior interventional diagnosis and/or treatment that may interfere with DNA information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Monocyte count and percentage;IL-1ß levels in peripheral blood and bone tissue;IL-4 level in peripheral blood and bone tissue;IL-6 level in peripheral blood and bone tissue;IL-10 level in peripheral blood and bone tissue;IL-18 level in peripheral blood and bone tissue;TNF-a level in peripheral blood and bone tissue;NLRP3 level in bone tissue;TAK1 level in bone tissue;GSDMD level in bone tissue;Bone tissue caspase3/6/7 level;Bone tissue p-MLKL level;HE staining of pathological sections of bone tissue;Masson staining of pathological sections of bone tissue;Immunohistochemistry; | — |
Secondary
| Measure | Time frame |
|---|---|
| Genotype of rs4353135 SNP site; | — |
Countries
China
Contacts
Public ContactJiang Nan
Southern Medical University Nanfang Hospital
Outcome results
None listed