cevical high-risk HPV infection
Conditions
Interventions
focused ultrasound group:focused ultrasound surgery
focused ultrasound and Lactobacillus group:focused ultrasound and Lactobacillus
focused ultrasound and interferon group:focused ultrasound and interferon
Sponsors
Chongqing University Three Gorges Hospital
Eligibility
Sex/Gender
Female
Age
22 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. The patient did not receive other drug, physical or surgical treatment within 3 months; 2. Women aged from 22 to 60 with a history of marriage and childbearing or sexual life; 3. Good mental condition, informed and cooperative with the research, signed the informed consent; 4. Chronic cervicitis, LSIL (CIN1), HSIL (CIN2 and CIN3) were diagnosed; 5. Detection of HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, 82, >=2 times positive, lasting more than 1 year with/without clinical symptoms, desire for treatment.
Exclusion criteria
Exclusion criteria: 1. Allergic to vaginal lactobacillus and interferon drugs; 2. In the acute stage of vaginitis, pregnancy and lactation; 3. History of cervical resection, total hysterectomy and pelvic radiation therapy; 4. Severe cardiovascular and cerebrovascular diseases, liver and kidney insufficiency, blood diseases, and coagulation mechanism disorders; 5. Severe immune system diseases, malnutrition and other diseases that affect and observe the effectiveness of treatment; 6. Pelvic inflammatory disease, colposcope type 3 and cervical cancer, uncontrolled diabetes, hyperthyroidism or hypothyroidism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall response efficiency and overturn rate of HR-HPV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Microecological change; | — |
Countries
China
Contacts
Public ContactHuang Mingju
Outcome results
None listed