coronary heart disease
Conditions
Interventions
Group P:use propofol for induction
Group E:use etomidate for induction
Sponsors
The First Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years; 2. Elective coronary artery bypass surgery; 3. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. IABP or ECMO assisted circulation was required before surgery; 2. Patients with more than moderate valvular disease or endocarditis; 3. Combined with other heart surgery: valve surgery and aortic replacement surgery; 4. Past heart surgery: major heart surgery requiring pericardium opening; 5. Severe arrhythmias: rapid atrial fibrillation, atrial flutter, ventricular tachycardia, ventricular fibrillation, degree II and degree III atrioventricular block, etc.; 6. Difficult airway; 7. Allergic to propofol, etomidate, Sufentanil, cis-atracurium, etomidate, sufentanil, cis-atracurium.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The relative change rate of left ventricle global longitudinal strain after induction compared with that before induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| The absolute change of left ventricle global longitudinal strain after induction compared with that before induction;Incidence of the relative change rate of left ventricle global longitudinal strain after induction compared with that before induction greater than 10%;Left ventricular ejection fraction;Mitral E/A ratios;The septal and lateral mitral E/e' ratios;Mitral E wave deceleration time;Tricuspid annular plane systolic excursion;Corrected flow time;Left ventricular end-systolic volume;Left ventricular end-diastolic volume;Stroke volume;Stroke volume index;Heart rate;Cardiac output;Cardiac index;Incidence of hypotension during induction; | — |
Countries
China
Contacts
Public ContactChen Yu
Outcome results
None listed