Urothelial carcinoma (UC)
Conditions
Interventions
Gold Standard:The final pathological diagnosis is taken as the gold standard: urothelial carcinoma is positive, non-urothelial carcinoma is negative, and other malignant tumors are excluded.
Index test:UCseek is a detection model combined methylation haploid load (MHL) with CNV. The UCseek score cutoff value is 0.46. If the score is more than 0.46, the patient would be classfied to urothe
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The experimental group: Patients who were initially diagnosed with urothelial carcinoma by clinical imaging (CT or MRI), and planned to undergo surgical treatment, and were finally confirmed as urothelial carcinoma by postoperative pathology. 2. The control group: Non-neoplastic diseases of the urinary system were excluded clinically (imaging and blood tumor markers ).
Exclusion criteria
Exclusion criteria: 1. Experimental group: (1) The patient has contraindications to surgery, so radical surgery cannot be performed to obtain pathology; (2) The patient had a history of bladder cancer, prostate cancer and other malignant tumors of the urinary system; (3) The patient proposed radical bladder resection in the short term and could not complete the follow-up study; (4) The patient refused to sign the informed consent and participate in the clinical study. 2. Control group: (1) Patients with bladder cancer, prostate cancer and other malignant tumors of urinary system; (2) The patient refused to sign the informed consent and participate in the clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Specificity;Positive predictive value;Negative predictive value;Overall consistency; | — |
Countries
China
Contacts
Public ContactZhou Liqun
Peking University First Hospital
Outcome results
None listed