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Conventional IVF for preimplantation genetic testing for mutation in ß-Thalassemia Carrier patients with non-male factor infertility

Conventional IVF for preimplantation genetic testing for mutation in ß-Thalassemia Carrier patients with non-male factor infertility

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200063919
Enrollment
Unknown
Registered
2022-09-20
Start date
2022-09-20
Completion date
Unknown
Last updated
2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thalassemia

Interventions

Experimental group:IVF insemination

Sponsors

Third Affiliated Hospital of Guangzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 38 Years

Inclusion criteria

Inclusion criteria: 1. Aged =15; 3. Male fresh injection semen (WHO normal semen standard: semen volume >=1.5ml; Sperm density >=15x10^6/ml; Forward-motile sperm ratio >=32%).

Exclusion criteria

Exclusion criteria: 1. Primary infertility >=3 years; 2. Repeated implantation failure (more than 3 embryo transfers or more than 4 high-quality embryos in total); 3. History of recurrent abortion (loss of 2 or more previous pregnancies, excluding biochemical pregnancy); 4. There are contraindications to assisted reproductive technology and pregnancy or diseases that have definite effects on pregnancy, including uncontrolled hypertension, heart disease with definite symptoms, uncontrolled diabetes, undiagnosed liver or kidney disease or liver or kidney insufficiency, and severe anemia; History of venous thrombosis, pulmonary embolism or cerebrovascular events, history of malignant tumors, suspected malignant tumors, undiagnosed abnormal uterine bleeding, clinically diagnosed major endocrine diseases; 5. Any other circumstances in which the investigator deems it inappropriate to participate in the study.

Design outcomes

Primary

MeasureTime frame
evaluate the accuracy of PGT-M results of IVF fertilized embryos;

Countries

China

Contacts

Public ContactLi Lei
lileigo@foxmail.com+86 13450477638

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026