postpartum depression
Conditions
Interventions
Control group:normal saline
Experimental group:esketamine
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Full-term (36-42w), single fetus, planned caesarean section; 2. ASA I or II; 3. 18 years old =150 cm; 5. Able to communicate fully and willing to accept the clinical trial and complete the postoperative follow-up; 6. Voluntary signatories of informed consent.
Exclusion criteria
Exclusion criteria: 1. Known allergy to esketamine or other drugs used in this study; 2. Long-term use of narcotic analgesics, sedatives or non-steroidal anti-inflammatory drugs; 3. Unstable mental disorders; 4. Severe electrocardiogram abnormality; 5. Severe hypertension and serious heart disease; 6. A history of drug or alcohol dependence exceeding 6 months; 7. Previous ketamine ineffective tests or adverse reactions; 8. Patients with coagulation dysfunction; 9. Complicated with craniocerebral injury and intracranial hypertension; 10. Severe abnormal heart, lung, liver and kidney function; 11. Participated in other drug clinical researchers in the past three months; 12. Patients deemed unsuitable for clinical trials by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Edinburgh Postnatal Depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale (VAS);Incidence of side reacton; | — |
Countries
China
Contacts
Public ContactYuan Baohong
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed