The post sepsis-induced functional reprogramming of MMP8 (+) dendritic cells contributes to T-cell exhaustion and secondary infection

Expression of MMP8 + DCS in sepsis and its clinical significance

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200063908

Enrollment

Unknown

Registered

2022-09-20

Start date

2022-09-20

Completion date

Unknown

Last updated

2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

Case series:Nil

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Aged >=18 years; 2. Signed informed consent; 3. EICU patients diagnosed with sepsis or septic shock according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

Exclusion criteria

Exclusion criteria: 1. Patients who died or were discharged within 24 hours of treatment with incomplete clinical data; 2. Participate in other researchers at the same time; 3. Patients with congenital acquired immune deficiency disease, long-term use of glucocorticoid or immunosuppressive drugs.

Design outcomes

Primary

Measure	Time frame
MMP8+DCs;Sequential Organ Failure Assessment Score (SOFA);Acute Physiological and Chronic Health Scores II;	—

Countries

China

Contacts

Public ContactZhao Guangju

zgj_0523@126.com+86 13819740236

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026