Metabolic Diseases
Conditions
Interventions
Group 1:Chinese medicine combined with a low-carb diet
Group 2:Low carbon diet alone
Group 3:Chinese medicine combined with conventional diChinese medicine combined with conventional dietet
Group 4:Regular Diet
Sponsors
Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Referring to the Guidelines for the Prevention and Control of Overweight and Obesity in Chinese Adults published in 2003, overweight or obese patients with 24 = BMI = 35 Kg/m2; combined with disorders of glucose metabolism, referring to the criteria of the Chinese Guidelines for the Prevention and Control of Type 2 Diabetes 2017 edition, the blood glucose range: fasting blood glucose 6.1-11 mmol/l or 2h postprandial or random blood glucose 7.8-16 mmol/l, and glycosylated hemoglobin 6.5%-10.0%. Pre-study, subjects who had not used glucose-lowering drugs were not allowed to use glucose-lowering drugs during the study period; pre-study, subjects who were on stable use of glucose-lowering, lipid-lowering, antihypertensive and other chronic disease drugs could still be enrolled, but it was ensured that they were not allowed to use additional glucose-lowering drugs during the study period. 2. age: =18 years and =70 years. 3. those without ketosis occurring within 3 months of onset and not yet on insulin therapy. 4. those who signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. patients with secondary obesity. 2. type 1 diabetes mellitus; type 2 diabetes mellitus patients with fasting glucose >11 mmol/l or 2h postprandial or random glucose >16 mmol/l or glycated hemoglobin >10.0%. 3. acute or severe chronic complications of diabetes such as diabetic ketosis or ketoacidosis, hyperosmolarity, or lactic acidosis. 4. recurrent episodes of severe hypoglycemia. 5. AST and ALT > 3 times the upper limit of normal; moderate to severe renal insufficiency (eGFR < 60 ml/min/1.73 m2 according to MDRD). 6. clinically significant cardiovascular disease episodes, including myocardial infarction, arrhythmia, conduction block with electrocardiographic manifestations (second degree type I and above), unstable angina or congestive heart failure (NYHA class III-IV). 7. pregnancy or planned pregnancy. 8. Possible hypersensitivity to the study drug or severe intestinal absorption dysfunction. 9. Those who cannot strictly comply with the requirements of the study and consciously cooperate with the study (meaning those who cannot cooperate with dietary control or cannot take the medication as prescribed and affect the efficacy). 10. Psychiatric patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body weight; | — |
Countries
China
Contacts
Public ContactSongWei
Guangdong Hospital of Traditional Chinese Medicine
Outcome results
None listed