The effective dose of remimazolam combined with esketamine for the endotracheal intubation without muscle relaxants in children by sequential method
Conditions
Interventions
2:Given the ED95 dose of esketamine
1:In the first stage,a fixed dose of remazolam was given intravenously,0.2mg/kg,and then different doses of esketamine were given sequentially.The ED50 and ED95 dose of esketamine were measured.
Sponsors
Shunde Hospital affiliated to Jinan University(Foshan Shunde Second People’s Hospitol?Feng Jingyao Memorial Hospital,Shunde District,Foshan City))
Eligibility
Sex/Gender
All
Age
No minimum to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age 3-6 years old, regardless of gender; 2. ASA score I or II; 3. Surgery under elective tracheal intubation and general anesthesia; 4. Parents of the child voluntarily participate in the study; 5. No contraindications for general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Previous history of iodine contrast agent allergy; 2. Patients with severe heart failure, arrhythmia or myocardial infarction and myocarditis; 3. Severe hepatic and renal insufficiency; 4. Pregnant patients; 5. Patients with chest pain (pulmonary embolism and aortic dissection).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Image quality evaluation; | — |
Countries
China
Contacts
Public ContactChen Jinming
Shunde Hospital affiliated to Jinan University(Feng Jingyao Memorial Hospital,Shunde Secend People's Hospitoal,Shunde District,Foshan City)
Outcome results
None listed