postoperative cognitive dysfunction
Conditions
Interventions
Postoperative cognitive dysfunction (POCD) group:None
non-Postoperative cognitive dysfunction (POCD) group:None
Sponsors
Zhongshan Hospital affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. The subject's age is>=65 years old, regardless of gender; 2. The patient meets the indications for orthopedic elective surgery (spine, joints, trauma); 3. During the screening period, the patient's liver and kidney functions were normal; 4. The patient has no evidence of acute infection with chronic diseases during the screening period; 5. Patients are able to understand the full nature and purpose of the study, including potential risks and side effects, collaborate with researchers, understand verbal and/or written instructions, and comply with the requirements of the entire study; 6. The patient (or legal guardian, if applicable) has been informed of the full nature and purpose of the study, including potential risks and side effects, given sufficient time and opportunity to read or understand relevant information, and signed and dated a written informed consent form before enrollment in the study; 7. The patient has an education age of 12 years or more and can successfully answer all cognitive scale related questions during the screening period.
Exclusion criteria
Exclusion criteria: 1. The researcher believes that there are situations in the subjects that may interfere with the research results; 2. Subjects with evidence of active liver disease (liver function test results: ALT or AST>=2 times the upper limit of normal value [ULN]) or with chronic active hepatitis B or hepatitis C within one month; 3. Active systemic infections requiring the use of antibiotics within one week prior to surgery; 4. Patients with one or more of the following diseases: 1) Classified as obese (body mass index>=30 kg/m2); 2) After insulin treatment, diabetes is still not under control; 3) Uncontrolled hypertension (defined as systolic blood pressure>=180 mmHg or diastolic blood pressure>=100 mmHg); 4) Have a history of lymphoma or tissue proliferative disease or bone marrow; 5) Have a history of organ transplantation, including cornea; 6) Suffering from any clinically significant uncontrolled respiratory system disease, including but not limited to chronic obstructive pulmonary disease, asthma, bronchiectasis, or pleural effusion; 7) Previously diagnosed or suspected of having demyelinating diseases, including multiple sclerosis, Guillain Barre syndrome, etc; 8) Any disease that significantly affects the nervous system? History of neurological and psychiatric disorders; 5. Other clinical trials are currently underway; 6. Patients with uncontrollable neurological, mental illness or mental disorder, poor compliance, and inability to cooperate; 7. Those who cannot understand the research protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasma protein levels;Cerebrospinal fluid protein levels; | — |
Countries
China
Contacts
Public ContactFang Hao
Zhongshan Hospital affiliated to Fudan University
Outcome results
None listed