Graves hyperthyroidism
Conditions
Interventions
Group 1:131i therapy
Group 2:Low dose antithyroid drugs
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
15 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Graves hyperthyroidism; 2. Age range from 15 to 65 years old; 3. There is no limit to gender; 4. After 6 to 12 months of 131I treatment, hyperthyroidism partially alleviates or relapses, and the thyroid gland is palpated as Grade I enlargement or no enlargement.
Exclusion criteria
Exclusion criteria: 1. ATD drug allergy; 2. Thyroid iodine uptake rate is less than or equal to 30%; 3. Contraindications to treatment, such as pregnancy/preparation for pregnancy, lactation, myocardial infarction, severe exophthalmos, severe liver and kidney diseases, hematopoietic system damage, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective rate (normal or reduced thyroid function); | — |
Secondary
| Measure | Time frame |
|---|---|
| therapy dose of L-T4 replacement for Hypothyroidism;cardiac function;Recurrence rate;Quality of life assessment (SF-36);Quality of life assessment (SF-36);Bone mineral density, BMD;Progress rate of hyperthyroidism ophthalmopathy;time to hypothyroidism; | — |
Countries
China
Contacts
Public ContactChao Ma
Shanghai Tenth People's Hospital
Outcome results
None listed