Helicobacter pylori
Conditions
Interventions
Group 1 :amoxicillin 750 mg qid + vonoprazan 20 mg bid
Group 2:amoxicillin 500 mg qid + vonoprazan 20 mg bid
Group 3:amoxicillin 1 g tid + vonoprazan 20 mg bid
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Elderly patients, aged 60-80 years; 2. Did not take antibiotics, bismuth and antibacterial active traditional Chinese medicine for 4 weeks before treatment, and did not take PPI, H2 receptor antagonists and other drugs that affect the activity of H.pylor for 2 weeks before treatment; 3. H. pylori infection was diagnosed as positive by 13C/14C urea breath test or rapid urease test or histological examination; 4. Patients have undergone gastroduodenoscopy at least within 1 year; 5. Patients are informed and agree to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Suffering from systemic lupus erythematosus, acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV) infection, or detection of hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody or HCV RNA Positive; creatinine level > 2 mg/dL (> 177 µmol/L); alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 2 times the upper limit of normal or total bilirubin > 2 times the upper limit of normal; or affected Subjects have a history or clinical manifestations of significant central nervous system, cardiovascular, pulmonary, hepatic, renal, metabolic, other gastrointestinal, urinary, endocrine or hematological diseases that the investigator believes will affect the results of the study or jeopardize subject safety; 2. Those who are allergic to penicillin, amoxicillin or vonolasan; 3. Patients with organic lesions such as gastrointestinal malignant tumors or gastrointestinal bleeding; 4. People with mental illness and communication disorders; 5. Those who are participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of helicobacter pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of compliance;Factors influencing eradication rate; | — |
Countries
China
Contacts
Public ContactDekui Zhang
Lanzhou University Second Hospital
Outcome results
None listed