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Effects of esketamine on perioperative brain function and intraoperative cerebral oxygen saturation in elderly patients: a randomized, double-blind, controlled clinical trial

Effects of esketamine on perioperative brain function and intraoperative cerebral oxygen saturation in elderly patients: a randomized, double-blind, controlled clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200063790
Enrollment
Unknown
Registered
2022-09-16
Start date
2022-09-16
Completion date
Unknown
Last updated
2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung cancer or other lung diseases

Interventions

Group 1 :use esketamine during operiation
Group 2:None

Sponsors

Sun Yat-sen University Cancer Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Patients who underwent abdominal (including abdominal and pelvic) tumor surgery, aged >= 60 years; 2. No mental disease or neurological disease in the past; 3. No cognitive dysfunction, no history of depression, no history of delirium after previous general anesthesia surgery; 4. Ability to provide informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients who underwent abdominal (including abdominal and pelvic) tumor surgery, aged >= 60 years; 2. No mental disease or neurological disease in the past; 3. No cognitive dysfunction, no history of depression, no history of delirium after previous general anesthesia surgery; 4. Ability to provide informed consent.

Design outcomes

Primary

MeasureTime frame
Delirium incidence;

Secondary

MeasureTime frame
Cognitive function;Depressive state;Opioid dosage;Incidence of complications;Cerebral oxygen saturation;C-reactive protein;S-100ß protein;

Countries

China

Contacts

Public ContactQiang Li

Sun Yat-sen University Cancer Center

liqiang@sysucc.org.cn+86 15918482688

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026