Skip to content

Efficacy evaluation of nirmatrelvir/ritonavir tablets on SARSC-CoV-2 infection-induced myocardial injury

Efficacy evaluation of nirmatrelvir/ritonavir tablets on SARSC-CoV-2 infection-induced myocardial injury

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200063778
Enrollment
Unknown
Registered
2022-09-16
Start date
2022-09-16
Completion date
Unknown
Last updated
2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid-19

Interventions

Group 1 :
Group 2:

Sponsors

Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age: over 18 years old, gender is not limited; 2. SARS-CoV-2 nucleic acid test positive; 3. Conform to the New Coronavirus Pneumonia Diagnosis and Treatment Plan (Trial Ninth Edition) new crown mild or common type; 4. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Acute coronary syndrome, acute heart failure, acute stroke; 2. Renal insufficiency (renal function eGFR < 30 ml/min/1.73m2); 3. Severe liver dysfunction (ALT/AST greater than 2.5 times the upper limit of normal); 4. Contraindications to the use of Naimatevir/ritonavir tablets; 5. Life expectancy is less than 24 months; 6. Unable to accept clinical follow-up.

Design outcomes

Primary

MeasureTime frame
myocardial injury;

Secondary

MeasureTime frame
high-sensitivity troponin peak;composite endpoints (nonfatal heart failure, nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death);

Countries

China

Contacts

Public ContactGu Jun

Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine

forrestgu@126.com+86 13917970451

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026